生物素缺乏对小鼠的致畸作用

• 作 者: 刘仁海
• 出 处: 石河子医学院学报
• 发表日期: 1984年01期
• 关键词: 生物素缺乏 致畸作用 并趾畸形 先天异常 鼠食 胚胎发育 代谢调节 小颌畸形 代谢物 大鼠

早期的研究报道缺乏生物素在鸡胚中可见到小肢和并趾畸形,在大鼠中若干脏器可出现组织学损害。本研究发现生物素缺乏,90％以上小鼠表现为外表或骨骼的先天异常,主要有小颌畸形、腭裂和小肢畸形。在母鼠食物中补充生物素可防止这些畸形的发生。生物素是多种羧化酶的辅因子,在糖的异生作用,脂肪酸合成,氨基酸分解代谢和糖代谢调节中起着重要作用。生物素缺乏使代谢广泛地受损,一些堆积的代谢物,可直接扰乱正常的胚胎发育。作者认

Earlier studies have reported lack of biotin in the chicken embryo can be seen in the small limbs and toe deformity, in some organs of rats may appear histological damage. This study found that biotin deficiency, more than 90% of mice showed appearance or bone congenital anomalies, mainly small jaw deformity, cleft palate and limb deformities. Supplementation of biotin in maternal food prevents these deformities. Biotin is a cofactor for many carboxylase enzymes and plays an important role in the regulation of gluconeogenesis, fatty acid synthesis, amino acid catabolism and glucose metabolism. Biotin deficiency extensively impairs metabolism, and some accumulated metabolites can directly disrupt normal embryonic development. The author recognizes