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目的:观察姜黄素对大鼠C6胶质瘤的抑制作用。方法:将SD大鼠随机分为假手术组、模型组、姜黄素高、低剂量组。各组动物于移植术后7天给予干预,姜黄素组给予姜黄素灌胃,14天后处死。分离肿瘤测量其体积,realtime RT-PCR法和western blot法检测肿瘤组织中核转录因子-κ B(nuclear factor-κ B,NF-κB)、EGFR mRNA和蛋白的表达。结果:姜黄素能明显降低肿瘤体积,降低肿瘤组织中NF-κ B、EGFR mRNA和蛋白的表达。结论:姜黄素能抑制大鼠C6胶质瘤的生长,其机制可能与抑制NF-κ B、EGFR表达有关。
Objective: To observe the inhibitory effect of curcumin on C6 glioma in rats. Methods: SD rats were randomly divided into sham operation group, model group, curcumin high and low dose groups. Each group of animals was given intervention 7 days after transplantation. Curcumin was given to the curcumin group for gavage and sacrificed after 14 days. The tumors were separated and their volume was measured. Real-time RT-PCR and western blot were used to detect the expression of nuclear factor-κB (NF-κB), EGFR mRNA and protein. Results: Curcumin significantly reduced tumor volume and decreased the expression of NF-κB and EGFR mRNA and protein in tumor tissue. Conclusion: Curcumin can inhibit the growth of C6 glioma in rats, which may be related to the inhibition of the expression of NF-κB and EGFR.