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目的探讨血清锌（Ｚｎ）、铜（Ｃｕ）含量变化在妇科肿瘤诊断上的价值。方法采用空气－乙炔火焰原子吸收分光光度法测定经组织学确诊的６３例妇科良、恶性肿瘤患者及４５例健康人血清锌、铜含量。结果卵巢癌患者血清锌含量明显降低，血清铜含量升高，与对照组比较均有显著性差异（Ｐ分别＜０．０１和０．００１）。良性肿瘤组血清锌、铜含量与对照组比较，差异无显著性意义（Ｐ＞０．０５）。结论血清锌、铜含量测定及Ｃｕ／Ｚｎ比值可作为妇科良、恶性肿瘤鉴别诊断或化疗疗效观察及预后判断的一项参考指标。
Objective To investigate the value of changes of serum zinc (Zn) and copper (Cu) in the diagnosis of gynecological tumors. Methods The levels of serum zinc and copper in 63 patients with benign and malignant gynecological diseases and 45 healthy people confirmed by histology were determined by air-acetylene flame atomic absorption spectrophotometry. Results Serum zinc levels in patients with ovarian cancer were significantly lower and serum copper levels were higher than those in the control group (P <0.01 and 0.001, respectively). There was no significant difference in serum zinc and copper levels between the benign tumor group and the control group (P> 0.05). Conclusion Determination of serum zinc and copper content and Cu / Zn ratio can be used as a good reference for the differential diagnosis or chemotherapy of gynecological benign and malignant tumors and prognosis.