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目的了解新疆维吾尔自治区(新疆)8月龄至6岁儿童乙型病毒性肝炎(乙肝)表面抗体(抗-HBs)水平,指导全区乙肝防控工作。方法采用二级抽样的方法,从全区94个县共抽取8月龄至6岁儿童4333名。用电化学发光免疫测定方法测定血清抗-HBs。结果 2013年新疆8月龄至6岁儿童乙肝疫苗全程接种率99.70%,抗-HBs阳性率59.40%,抗体几何平均滴度(GMC)30.1 m IU/ml。各地区间乙肝疫苗全程接种率差异无统计学意义(χ~2=12.105,P>0.05),抗-HBs阳性率差异有统计学意义(χ~2=494.46,P<0.01),GMC差异有统计学意义(F=35.27,P<0.01)。各年龄组间抗-HBs阳性率波动在50.50%~79.00%之间,差异有统计学意义(χ~2=216.56,P<0.01),GMC差异有统计学意义(F=26.83,P<0.01)。不同民族间抗-HBs阳性率波动在44.50%~80.70%之间,维吾尔族最低(44.50%),各民族抗-HBs阳性率差异有统计学意义(χ~2=444.99,P<0.01),GMC差异有统计学意义(F=45.27,P<0.01)。结论在提高疫苗接种率的同时,要进一步加强冷链管理和规范操作规程,提高疫苗的有效接种,同时应继续大力开展乙肝疫苗少数民族语言宣传工作。
Objective To understand the level of hepatitis B surface antigen (anti-HBs) in children aged 8 months to 6 years in Xinjiang Uygur Autonomous Region (Xinjiang Uygur Autonomous Region) and to guide the prevention and control of hepatitis B in the whole region. Methods A total of 4333 children aged from 8 months to 6 years were collected from 94 counties in the district by the method of two-stage sampling. Serum anti-HBs were measured by electrochemiluminescence immunoassay. Results In 2013, the overall vaccination rate of hepatitis B vaccine was 99.70%, the anti-HBs positive rate was 59.40%, and the geometric mean antibody titer (GMC) was 30.1 mIU / ml in Xinjiang children aged 6 months to 6 years. There was no significant difference in the whole vaccination rate of hepatitis B vaccine between regions (χ ~ 2 = 12.105, P> 0.05). The positive rate of anti-HBs was statistically significant (χ ~ 2 = 494.46, P <0.01) Significance (F = 35.27, P <0.01). The positive rate of anti-HBs in all age groups fluctuated between 50.50% -79.00%, the difference was statistically significant (χ ~ 2 = 216.56, P <0.01), the difference was statistically significant (F = 26.83, P <0.01 ). The positive rates of anti-HBs in different ethnic groups fluctuated between 44.50% and 80.70%, the lowest among Uighurs (44.50%) and the anti-HBs positive rates in all ethnic groups were statistically significant (χ ~ 2 = 444.99, P <0.01) GMC difference was statistically significant (F = 45.27, P <0.01). Conclusions While raising the vaccination rate, we should further strengthen the management of cold chain and standard operating procedures so as to improve the effective vaccination of vaccines. At the same time, we should continue to vigorously carry out the propaganda work of minority hepatitis B vaccines.