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骨髓来源的间质干细胞(mesenchymal stem cells,MSCs)可分化为脂肪细胞和成骨细胞,二者分化平衡受到过氧化物酶体增殖物激活受体(peroxisome proliferator-activated receptorγ,PPARγ)的调控,然而PPARγ对该过程的具体调节机制尚不清楚。MSCs向脂肪细胞和成骨细胞的不均衡分化可导致多种疾病,如骨质疏松症、异位骨形成、代谢性疾病等,而PPARγ作为MSCs分化调节的关键因子在多种层面影响这一生理过程。前期研究显示,细胞内NO水平对MSCs分化有重要意义,而NO
Bone marrow-derived mesenchymal stem cells (MSCs) can differentiate into adipocytes and osteoblasts. The balance of the two is regulated by peroxisome proliferator-activated receptorγ (PPARγ) However, the specific regulation mechanism of PPARγ on this process is not yet clear. The uneven differentiation of MSCs into adipocytes and osteoblasts can lead to various diseases such as osteoporosis, ectopic bone formation and metabolic diseases, and PPARγ, as a key factor in the regulation of MSCs differentiation, affects this in many aspects Physiological process. Preliminary studies have shown that intracellular NO levels have important implications for MSCs differentiation, whereas NO