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镉在工业上应用十分广泛,是重要的环境污染物,控制镉的危害是环境与职业医学的重要课题。肾是镉的主要靶器官之一,本课题研究镉对肾的超微结构,超氧化物歧化酶(SOD)活性及其mRNA转录的影响,以进一步揭示镉对肾的氧化损伤机制。实验用雄性SD成年大鼠50只,随
Cadmium is widely used in industry and is an important environmental pollutant. It is an important issue of environmental and occupational medicine to control the harm of cadmium. Kidney is one of the main target organs of cadmium. In this study, we investigated the effects of cadmium on the ultrastructure of kidney, the activity of superoxide dismutase (SOD) and the transcription of mRNA, so as to further reveal the mechanism of oxidative damage of cadmium to the kidneys. Fifty male SD rats were used in the experiment