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为探讨疗效确切、疗程短、副作用小的化疗方案治疗妊娠滋养细胞肿瘤，本研究应用卡铂、氨甲喋呤、长春新碱（ＣＭＶ方案）三联治疗妊娠滋养细胞肿瘤４６例，与随机抽取同期应用５—氟脲嘧啶与更生霉素（双枪组）２３例进行疗效、副作用对照。结果发现ＣＭＶ组初治３５例全部治愈，耐药病例８例治愈，总治愈率９３５％（４３／４６），与对照组比较两者治愈率、耐药性发生率、血β—ＨＣＧ各疗程转阴率无明显差异。但ＣＭＶ组消化道反应、口腔溃疡、腹泻的发生率低于对照组，且差异有显著性。说明ＣＭＶ方案治疗妊娠滋养细胞肿瘤疗效确切、疗程短、副作用小、患者易于接受。尤其对初治病例效果好，对其他方案耐药者也有较好疗效，可作为治疗妊娠滋养细胞肿瘤的有效化疗方案之一。
In order to explore the curative effect, short course of treatment and small side effect chemotherapy regimen for treatment of gestational trophoblastic tumor, 46 cases of gestational trophoblastic tumor were treated with carboplatin, methotrexate and vincristine (CMV regimen) in this study. Fluorouracil and dactinomycin (double gun group) 23 cases of efficacy, side effects of the control. The results showed that the initial treatment of 35 cases of CMV group were cured, 8 cases of resistant cases were cured, the total cure rate 935% (43/46), compared with the control group, the cure rate, the incidence of drug resistance, β-HCG There was no significant difference in the rate of negative conversion between treatments. However, the incidence of digestive tract reaction, oral ulcer and diarrhea in CMV group was lower than that in control group, and the difference was significant. Description of CMV regimen gestational trophoblastic tumor curative effect is accurate, short course, side effects, patients are easy to accept. In particular, the effect of initial treatment is good, resistant to other programs have a good effect, can be used as an effective treatment of gestational trophoblastic tumor chemotherapy program.