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检测整合素β３及细胞外基质纤维粘连蛋白（ＦＮ）、层粘连蛋白（ＬＮ）、Ⅳ型胶原纤维（ＣＬ）在生育组及原因不明不孕组妇女分泌期子宫内膜上的表达，探讨其变化规律及在调控妊娠中的作用。生育组３１例，原因不明不孕组３４例；采用免疫组化方法测定。结果显示整合素β３在生育组腺上皮细胞分泌中期出现，持续至分泌晚期，而不孕组分泌期无表达；细胞外基质在生育组分泌中期呈强表达，早期次之，晚期较弱，不孕组在分泌各期表达均高于生育组。说明整合素β３和ＦＮ、ＬＮ、Ⅳ型ＣＬ在月经周期分泌期子宫内膜上呈周期性变化，参与子宫内膜的功能变化及胚泡的着床环节，其异常表达可致着床失败而不孕。
To detect the expression of integrin β3, extracellular matrix fibronectin (FN), laminin (LN) and collagen type Ⅳ (CL) in the endometrium during the secretory phase in fertile and unexplained infertile women Variations and their roles in the regulation of pregnancy. 31 cases of fertility group, 34 cases of unexplained infertility group; using immunohistochemical method. The results showed that integrin β3 appeared in the middle stage of glandular epithelial cell secretion in the reproductive group and continued to the late stage of secretion, but not in the secretory phase of the infertility group. The extracellular matrix was strongly expressed in the middle part of the reproductive stage, followed by the early stage and late stage, Pregnant group in the secretion of all stages were higher than the fertility group. These results indicate that integrin β3 and FN, LN, and type Ⅳ CL undergo periodic changes during the secretory phase of the menstrual cycle and participate in the functional changes of the endometrium and the implantation of blastocyst. Abnormal expression of CL may lead to implantation failure Infertility.