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在各种药物相互作用中,降血糖药占第二位,且严重的低血糖可危及生命,故应引起重视。为此作者在临床处方中所见到的降血糖药甲磺丁脲与其它药物相互作用加以阐述,以供参考。甲碘丁脲的临床药理甲磺丁脲(甲糖宁)主要是通过直接刺激胰岛β细胞,释放胰岛素而发挥降血糖作用。同时,还能抑制胰岛的α细胞,减少胰高血糖素(GLucagon)的分泌,也可使血糖降低。反复用药可刺激胰岛β细胞增生。对胰腺完全切除的实验糖尿病动物则无降血糖作用。临床疗效也证实,甲磺丁脲只对胰腺功能尚未完全丧失(至少保留正常的30％)的患者有效。
In a variety of drug interactions, hypoglycemic agents account for the second place, and severe hypoglycemia can be life-threatening, it should be taken seriously. For this reason, the author in the clinical prescription to see the hypoglycemic drug methotrexate and other drug interactions are described for reference. Clinical Pharmacology of Methyliodourea Mebutamide (mellitus) exerts the hypoglycemic effect by directly stimulating islet β-cells and releasing insulin. At the same time, but also inhibit islet cells, reduce the secretion of glucagon (GLucagon), but also make blood sugar. Repeated medication can stimulate pancreatic β-cell proliferation. Experimental diabetic animals with complete resection of the pancreas have no hypoglycemic effect. Clinical efficacy also confirms that metoxicamide is effective only in patients who have not yet had complete loss of pancreatic function (at least retaining a normal 30%).