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1.青霉素与常用输液的配伍青霉素的水溶液很不稳定,最适 pH 值6～7,当温度下降或温度上升时易被破坏而失效。青霉素与葡萄糖及碳水化合物混合后,由于后者 pH 值为4左右,稳定性下降,可催化青霉素分解而降效。碳水化合物浓度越高,分解越快,其分解产物比青霉素更具有抗原性,是产生过敏反应的重要原因之一。盛夏季节不宜用5%或10%G S 稀释、静滴大剂量青霉素,因在室温低于20℃和在25℃使用时,分别不宜超过4小时和2小时;室温达37℃,青霉素溶
Penicillin and common infusion compatibility Penicillin aqueous solution is unstable, the optimum pH value of 6 to 7, when the temperature dropped or the temperature rise easily damaged and failed. Penicillin and glucose and carbohydrates after mixing, because the latter pH value of about 4, the stability of the decline can be catalyzed by penicillin decomposition and efficiency. The higher the concentration of carbohydrates, the faster the decomposition, the decomposition products are more antigenic than penicillin, is one of the important causes of allergic reactions. Should not be diluted with 5% or 10% G S in midsummer, intravenous infusion of high-dose penicillin should not exceed 4 hours and 2 hours at room temperature below 20 ℃ and at 25 ℃ respectively; at room temperature of 37 ℃,