Mutant amyloid precursor protein and presenilin-1 genes effect on ischemia vulnerability via calcium

• 作 者: Liangyu Zou Xiaofan Chu Haiyan
• 机 构: DepartmentofNeurology,IntensiveCareUnit
• 出 处: 中国神经再生研究：英文版
• 发表日期: 2009年12期
• 关键词: 淀粉样前体蛋白 缺血性脑损伤 转基因小鼠 钙稳态 突变型 fluo-3/AM 超氧阴离子 干扰 amyloid precursor protein presen
• 基金项目: Shenzhen Science Technology Project from Shenzhen Bureau of Science Technology and Information, No. 200702029 Medicial Science Technology Research Fund of Guangdong Province, No. A2008601＆ A2007570

<正> BACKGROUND: Previous studies have demonstrated that mutant amyloid precursor protein (APP)or presenilin-1 (PS1) genes increase susceptibility to ischemic brain damage induced by middlecerebral artery occlusion. Possible mechanisms include over-p