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目的了解我院儿童抗感染药物不良反应的发生特点,促进临床合理用药。方法对我院2005年1月至2009年12月共收集到的112例儿童抗感染药物不良反应(ADR)报告,进行回顾性统计和分析。结果 112例ADR中,主要与抗感染药物使用、注射剂联合应用的种类、静脉给药的方式及患者年龄偏小有关,ADR最常见表现为累及的系统-器官以皮肤及附件损害为多见。结论加强ADR监测,合理使用抗感染药物,尽量避免联合应用注射剂,减少ADR的发生。
Objective To understand the characteristics of adverse reactions of anti-infective drugs in our hospital and to promote the rational use of drugs. Methods A total of 112 cases of ADR reported in our hospital from January 2005 to December 2009 were retrospectively analyzed and statistically analyzed. Results 112 cases of ADR were mainly related to the use of anti-infective drugs, the type of combination used for injection, the way of intravenous administration and the patients’ younger age. The most common manifestation of ADR was the systemic-organ involvement, which was more common in skin and accessory lesions. Conclusion To strengthen the monitoring of ADR and to use anti-infectives reasonably, try to avoid joint injection and reduce the occurrence of ADR.