IFN-α对慢性乙型肝炎患者血清NO的影响

• 作 者: 陈焰 田德英 宋佩辉
• 机 构: 同济医科大学附属同济医院,同济医科大学附属同济医院,同济医科大学附属同济医院 武汉 430030,武汉 430030,武汉 430030
• 出 处: 中西医结合肝病杂志
• 发表日期: 1999年06期
• 关键词: 乙型肝炎 IFN-α 乙肝患者血清 慢性乙肝 健康献血员 疗效考核 试剂盒检测 慢性肝炎 γ-干扰素 慢性病毒性肝炎

目的:探讨IFN-α对慢性乙型肝炎患者血清NO的影响。方法:IFN-α治疗慢性乙型肝炎患者60例,疗程1个月、3个月、6个月和9个月各15例,另以15例病情相同而未经治疗的慢性乙肝患者作为治疗前对照;15例健康献血员作为正常对照。用NO试剂盒检测血清NO浓度。结果:治疗前慢性乙肝患者血清NO浓度显著升高,经IFN-α治疗后,血清NO浓度显著降低。结论:NO可作为IFN-α疗效考核指标之一。

Objective: To investigate the effect of IFN-α on serum NO in patients with chronic hepatitis B Methods: Sixty patients with chronic hepatitis B were treated with IFN-α. Fifteen patients were treated with one month, three months, six months and nine months respectively. Fifteen patients with identical chronic hepatitis B Before the control; 15 healthy blood donors as a normal control. Serum NO concentration was measured using the NO kit. Results: Serum NO concentration in patients with chronic hepatitis B before treatment was significantly increased. After IFN-α treatment, the serum NO concentration was significantly lower. Conclusion: NO can be used as an indicator of the efficacy of IFN-α.