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目的统计分析2014年1月~2016年12月在山东大学附属生殖医院(山大生殖)就诊的91 331例不孕不育患者的TORCH病原体感染检测结果,探讨该人群TORCH感染情况,以分析TORCH感染对不孕不育的影响,为优生优育提供支持。方法回顾性分析。2014年1月~2016年12月在山大生殖就诊的91 331例患者TORCH资料,利用化学发光免疫分析法进行的TORCH免疫球蛋白抗体IgM和IgG的检测结果,进行数据统计。结果 91 331例不孕患者血清TORCH CMV-IgM、HSV-IgM、RVIgM、TOXO-IgM的阳性率分别为0.39%、11.83%、0.82%、0.25%;CMV-IgG、HSV-IgG、RV-IgG、TOXO-IgG的阳性率分别为97.00%、95.98%、82.46%、0.86%。TOXO感染的阳性率最低。TORCH急性感染CMV、HSV阳性率存在性别差异,而在既往感染CMV、HSV、RV均表现出了性别差异性,且均以女性的感染率较高。该地区TORCH病原体CMV、HSV、RV的感染模式均以IgM-/IgG+为主,而TOXO则主要表现为IgM-/IgG-模式。男性和女性患者急性感染的HSV的阳性率存在显著的年龄差异,而CMV、RV、TOXO各年龄段间差异无统计学意义,但整体呈现阳性率随年龄增大而降低的趋势。不孕不育群体男性TORCH四种病原体感染阳性率季节差异没有统计学意义,而女性CMV的感染阳性率存在季节差异以冬春季的感染阳性率较高,其他三种病原体感染阳性率亦无明显季节差异。结论山东地区不孕不育患者急性感染以HSV-IgM为主,既往感染则以CMV-IgG、HSV-IgG为主,TOXO感染的阳性率最低。TORCH的某些病原体感染存在性别、年龄、季节感染差异。
Objective To analyze and analyze the TORCH pathogen infection in 91 331 infertile patients who visited the Affiliated Reproductive Hospital Affiliated to Shandong University from January 2014 to December 2016. To investigate the TORCH infection in this population to analyze the TORCH infection The impact of infertility, to provide support for prenatal and postnatal care. Methods Retrospective analysis. TORCH data of 91 331 patients who received DSM from January 2014 to December 2016 were analyzed. The results of TORCH immunoglobulin IgM and IgG detected by chemiluminescence immunoassay were statistically analyzed. Results The positive rates of TORCH CMV-IgM, HSV-IgM, RVIgM and TOXO-IgM in 91 331 infertile patients were 0.39%, 11.83%, 0.82% and 0.25% The positive rates of TOXO-IgG were 97.00%, 95.98%, 82.46% and 0.86% respectively. TOXO infection the lowest positive rate. TORCH acute infection CMV, HSV positive rate of gender differences, while in the past infection of CMV, HSV, RV showed a gender difference, and both women with a higher infection rate. The patterns of infection of CMV, HSV and RV of TORCH pathogens in this area are mainly IgM- / IgG +, while TOXO is predominantly IgM- / IgG- mode. There was a significant difference in the positive rates of HSV infection between male and female patients, but there was no significant difference between CMV, RV and TOXO among all age groups. However, the overall positive rate of HSV decreased with age. There was no significant difference in seasonal positive rates of the four pathogens of TORCH among infertile men, while there was a seasonal difference in the positive rates of CMV among women in winter and spring, and no significant positive rates were found in the other three pathogens Seasonal differences. Conclusion The main infective infertility patients in Shandong Province are HSV-IgM, while the former are mainly CMV-IgG and HSV-IgG, while the lowest is TOXO infection. TORCH infection of some pathogens exist gender, age, seasonal differences in infection.