Biological Significance and the Related Molecular Mechanism of Ets1 mRNA Expression in Lung Cancer b

• 作 者: SONG Wen-jing WANG Xin-yun SUN Cui-yun
• 机 构: Department of Pathology,Tianjin Medical University,Tianjin 300070
• 出 处: 中国癌症研究（英文版）
• 发表日期: 2007年3期
• 关键词: Tissue microarray (TMA) Lung cancer Precancerous lesion Ets-1 mRNA TGFβ1 protein

Objective: To investigate the expressions and molecular mechanism of Ets-1 mRNA, and TGFβ1 and c-Met proteins in the pathogenesis, progression of lung cancer by tissue microarray (TMA) method. Methods: The expressions of Ets-1 mRNA, and TGFβ1 and c-Met proteins were detected in 89 primary lung cancers, 12 lung cancer with lymph-node metastasis and 12 precancerous lesions by FISH(fluorescence in situ hybridization) and immunohistochemical method, and 10 normal lung tissues were used as controls. Results: The expressions of Ets-1 mRNA, and TGFβ1 and c-Met proteins were significantly higher in 89 primary lung cancer than in the control group (P＜0.05). The expressions of Ets-1 mRNA, and TGFβ1 and c-Met proteins were related to lymph node metastasis and clinical stages. There was a positive correlation between the Ets-1 mRNA expression and TGFβ1 and c-Met proteins (P＜0.05). Conclusion: Ets-1 mRNA, TGFβ1 and c-Met proteins may be related to the pathogenesis, progression and malignant behavior of lung cancer. They may play an important role in prognosis assessment of lung cancer.