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用透射电镜观察并结合形态计量法研究慢性镉中毒时小鼠睾丸支持细胞及血－睾屏障的超微结构。结果表明：（１）支持细胞明显受损，细胞核增大，细胞器出现变性，有的支持细胞呈现坏死。（２）血－睾屏障各部分受损，间质内血管内皮细胞变性、坏死、剥脱；生精小管基膜增厚、分裂成层；管周组织内胶原原纤维显著增多；相邻支持细胞间紧密连接破坏。从形态结构方面考虑，认为血－睾屏障的瓦解可能是引发生精异常的主要原因。
Transmission electron microscopy and morphometry were used to investigate the ultrastructure of testis-supporting cells and blood-testis barrier in mice with chronic cadmium poisoning. The results showed that: (1) The supporting cells were obviously damaged, the nucleus was enlarged, the organelles were degenerated, and some of the supporting cells were necrotic. (2) Each part of the blood-testis barrier was impaired, degeneration, necrosis and exfoliation of vascular endothelial cells in the interstitium. The basement membrane of thickened seminiferous tubules was thickened and divided into layers. The number of collagen fibrils in the peritumoral tissues was significantly increased. Adjacent supporting cells Close connection between the destruction. From the aspect of morphological structure, it is considered that the disruption of the blood-testis barrier may be the main cause of abnormal spermatogenesis.