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目的探讨丙氨酰谷氨酰胺对慢性阻塞性肺疾病急性加重期(AECOPD)合并呼吸衰竭患者的营养治疗作用和对呼吸机治疗效果观察。方法选择52例AECOPD合并呼吸衰竭患者,随机分为治疗组和对照组,各26例。给予等热量、等氮量的营养支持及有创呼吸机支持通气,对照组给予常规临床治疗。治疗组在对照组的基础上加用丙氨酰谷氨酰胺治疗,观察两组治疗前、治疗第10天的动脉血气,治疗前及治疗第10天的血清白蛋白、总蛋白的变化,并评价治疗效果。并观察在10天内成功脱机的例数。结果治疗组治疗第10天动脉血气分析及各营养指标明显优于对照组(P<0.05),两组在成功脱机的百分比差异无统计学意义,但治疗组在成功脱机的例数有增加的倾向。结论联合应用丙氨酰谷氨酰胺对AECOPD合并呼吸衰竭患者有一定的治疗作用。
Objective To investigate the nutritional therapeutic effect of alanylglutamine on patients with acute exacerbation of chronic obstructive pulmonary disease (AECOPD) complicated with respiratory failure and the therapeutic effect of ventilator. Methods Fifty-two AECOPD patients with respiratory failure were randomly divided into treatment group and control group, with 26 cases in each group. To give equal heat, nourishment and nitrogen nutrition support invasive ventilator support ventilation, the control group given routine clinical treatment. The treatment group was treated with alanylglutamine on the basis of the control group, and the changes of serum albumin and total protein before treatment and on the 10th day of treatment were observed before treatment, arterial blood gas on the 10th day of treatment, and Evaluation of treatment. And observe the number of successful offline in 10 days. Results The arterial blood gas analysis and nutritional indexes on the 10th day after treatment in the treatment group were significantly better than those in the control group (P <0.05). There was no significant difference in the percentage of successful off-line between the two groups, but there were Increased tendency. Conclusions Combination of alanylglutamine and AECOPD in patients with respiratory failure have a certain therapeutic effect.