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目的:探讨喹诺酮类药物致不良反应(ADR)的特点,为其临床合理应用提供参考。方法:收集2004年1月-2011年1月我院应用喹诺酮类抗菌药物致ADR的临床资料,进行总结、分析。结果:我院共报告129例喹诺酮类致ADR,涉及8个药品种类,左氧氟沙星最多,发生86例,占66.67%;从受损系统或器官看,皮肤及附件最多,发生49例,占37.98%。结论:临床应重视合理使用喹诺酮类抗菌药物,杜绝或减少ADR的重复发生。
Objective: To investigate the characteristics of quinolone-induced adverse reactions (ADRs) and provide references for their clinical application. Methods: Clinical data of ADR induced by quinolone antibiotics in our hospital from January 2004 to January 2011 were collected and analyzed. Results: A total of 129 cases of quinolone-induced ADR were reported in our hospital. Of the 8 drugs, levofloxacin was the most common type in 86 cases (66.67%). Most of the skin and appendages were seen from the damaged system or organs, accounting for 37.98% . Conclusion: Clinical should pay attention to the rational use of quinolone antibacterial drugs to eliminate or reduce the recurrence of ADR.