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恶性肿瘤的一个重要特性即是瘤细胞的失控性增生。随着人们对细胞增生和分化机制认识的加深,已把研究重点转向对正常和恶性瘤细胞的增生抑制方面。维生素 A 及其衍生物则为对此有重要贡献的药物。早在1925年,已认识到维生素 A与肿瘤的关系。当时,Worbach 和 Howe 对在维生素 A 缺乏时正常特化的上皮细胞被化生的鳞状上皮取代的现象作了描述。继之,日本学者 Fujimaki 提出维生素 A 缺
An important feature of malignant tumors is the uncontrolled proliferation of tumor cells. As people become more aware of the mechanism of cell proliferation and differentiation, the emphasis has shifted to the inhibition of proliferation of normal and malignant tumor cells. Vitamin A and its derivatives are drugs that make an important contribution to this. As early as 1925, the relationship between vitamin A and cancer has been recognized. At the time, Worbach and Howe described the replacement of squamous epithelium normalized epithelium in the absence of vitamin A with metaplastic squamous epithelium. Then, Japanese scholar Fujimaki proposed Vitamin A deficiency