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药物在气相色谱分析前进行衍生化主要是为减少极性以避免痕量化合物在柱上吸附.并可引入适合选择性和灵敏性检测的标记.一般在衍生化之前需先提取分离生物样品中的待分析物.目前人们一直努力把提取分离和衍生化合为一步.不经分离而直接衍生化能改善极性化合物的提取性能.如果在取样后立即进行衍生化,可以避免一些待分析物的不稳定和在分离过程中在玻璃器皿上的吸附.提取烷基化反应:可以用于以阴离子形式
Derivatization of the drug prior to GC analysis is primarily to reduce the polarity to prevent the adsorption of trace compounds on the column, and to introduce suitable markers for selectivity and sensitivity detection. It is generally necessary to first extract the biological sample before derivatization Of the analytes present At present, people have been striving to take the separation and derivatization into one step directly without isolation and derivatization can improve the extraction performance of polar compounds.If the sample is immediately after the derivatization, to avoid some of the analyte Instability and adsorption on glassware during separation Extraction Alkylation: can be used in anionic form