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乙酰唑胺钠(又名醋唑磺胺钠)是广泛用于内科的碳酸酐酶抑制剂,为治疗某些类型青光眼及异常水潴留如心脏性水肿病人的利尿剂。乙酰唑胺钠灭菌粉末常与5％葡萄糖或0.9％氯化钠注射液混合作静脉滴注。因此,本文用高效液相色谱分析,研究了乙酰唑胺钠在上述两液中的化学稳定性,结果见附表。由附表看出,含乙酰唑胺钠(0.375mg/ml)的5％葡萄糖或0.9％氯化钠注射液,在25℃下贮存5d是稳定的,其效价损失小于7.2％,溶液澄明,5％葡萄糖液的pH值由8.7降至8.0,0.9％氯化钠液的pH值由8.9降至8.4。pH值的降低是由于分解出的醋酸所致。5℃下贮存44d,该药在两液中的效价损失小于6％,溶
Acetazolamide sodium (also known as acetosulfuron sodium) is a carbonic anhydrase inhibitor widely used in medicine for the treatment of diuretics in certain types of glaucoma and patients with abnormal water retention such as cardiac edema. Sodium acetazolamide sterile powder often mixed with 5% glucose or 0.9% sodium chloride injection for intravenous drip. Therefore, in this paper, high-performance liquid chromatography analysis of the chemical stability of sodium acetazolamide in the two liquids, the results are attached. It can be seen from the attached table that 5% dextrose or 0.9% sodium chloride injection containing sodium acetazolamide (0.375 mg / ml) is stable after storage for 5 d at 25 ° C with a titer loss of less than 7.2% , The pH of 5% glucose solution decreased from 8.7 to 8.0, and the pH value of 0.9% sodium chloride solution decreased from 8.9 to 8.4. The decrease in pH is due to the decomposition of acetic acid. Stored at 5 ℃ for 44 days, the drug lost less than 6% titer in two liquids and dissolved