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目的观察联合应用依达拉奉与丹参注射液对急性脑梗死患者血清同型半胱氨酸(Hcy)水平影响及临床疗效。方法选择2012年1月至2013年1月75例急性脑梗死患者,随机分为实验组38例和对照组37例。两组均给予基础对症治疗,实验组在基础治疗基础上加用依达拉奉和丹参注射液,对照组加用丹参注射液。于治疗前及治疗第15天测定血清Hcy水平,同时对患者神经功能缺损进行评分。结果治疗前实验组和对照组血清Hcy水平差异无统计学意义(P>0.05)。实验组在治疗第15天血清Hcy水平明显改善(P<0.05),且较对照组明显降低,差异有统计学意义(P<0.05),而对照组血清Hcy水平治疗前后差异无统计学意义(P>0.05)。治疗前两组患者神经功能缺损评分比较差异无统计学意义(P>0.05)。实验组在治疗第4、7、15天神经功能缺失评分较入院时明显改善(P<0.05),对照组在治疗第7、15天出现神经功能改善(P<0.05),治疗第15 d实验组评分明显低于对照组,差异有统计学意义(P<0.05)。结论依达拉奉联合丹参注射液治疗急性脑梗死疗效显著,有利于减轻神经损伤程度。
Objective To observe the effect of edaravone and salvia miltiorrhiza injection on serum homocysteine (Hcy) level in patients with acute cerebral infarction and its clinical efficacy. Methods From January 2012 to January 2013, 75 patients with acute cerebral infarction were randomly divided into experimental group (38 cases) and control group (37 cases). The two groups were given basic symptomatic treatment, experimental group based on the basic treatment plus edaravone and Salvia injection, the control group plus Salvia injection. Serum Hcy levels were measured before treatment and on the 15th day of treatment, and patients’ neurological deficits were scored. Results There was no significant difference in serum Hcy level between the experimental group and the control group before treatment (P> 0.05). The level of serum Hcy in the experimental group was significantly improved on the 15th day (P <0.05), which was significantly lower than that of the control group (P <0.05), while there was no significant difference in the serum Hcy level before and after treatment P> 0.05). There was no significant difference in neurological deficit scores between the two groups before treatment (P> 0.05). The neurological deficit scores of the experimental group on the 4th, 7th and 15th days after treatment were significantly improved (P <0.05), while those of the control group were improved on the 7th and 15th days (P <0.05) Group score was significantly lower than the control group, the difference was statistically significant (P <0.05). Conclusion Edaravone combined with Salvia injection treatment of acute cerebral infarction significant effect, help to reduce the degree of nerve injury.