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目的 探讨急诊经皮冠状动脉介入治疗(percutaneous coronary intervention,PCI)术前给予80 mg阿托伐他汀强化治疗对ST段抬高心肌梗死(ST-segment elevation myocardial infarction,STEMI)患者术后ST段回落、血清炎症因子及内皮功能的影响.方法 发病0.05).术后3 d和7 d,A组的hs-CRP水平均显著低于B组、C组(均P0.05).术后24 h及术后3 d A、B、C三组间NOS水平均无统计学差异(均P>0.05);术后7 d A组NOS水平显著高于其他两组(均P0.05).结论 急诊PCI术前给予80 mg阿托伐他汀强化治疗有利于术后心电图ST段回落,改善心肌灌注;同时可显著降低术后血清炎性因子水平,改善血管内皮功能.“,”Objective To evaluate the effects of intensive treatment with 80 mg atorvastatin before primary percutaneous coronary intervention (PCI) on ST-resolution, inflammation response and endothelial function in ST-segment elevation myocardial infarction (STEMI)patients. Methods 95 patients of ST-segment elevation acute myocardial infarction (STEMI) with the onset time0.05). The serum NOS level 7 days after PCI of Group A was significantly higher than those of Groups B and C (both P>0.05); however, there were no significant differences in the serum NOS levels 7 days after PCI between Groups B and C (P>0.05). Conclusion Intensive treatment of 80 mg atorvastatin before primary PCI benefits the resolution of ST-segment elevation as well as the myocardial perfusion, lowers the extent of inflammation, and improves vascular endothelial function.