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为观察高温、臊声对大鼠脑皮层线粒体Ca~(2+)、Mg~(2+)含晕的影响,用原子吸收分光光度计对大鼠脑线粒体ca~(2+)、Mg~(2+)含量进行测定。结果发现(1)高温组脑线粒体Ca~(2+)明显升高,与对照组、噪声组及复合组比较均有非常显著性差异(P<0.01);(2)复合组脑线粒体Ca~(2+)明显减少,与对照组比较有显著性差异(P<0.05);(3)高温组、噪声组及复合组与对照组比较,脑线粒体Mg~(2+)无显著变化(P>0.05),似复合组Mg~(2+)明显高于噪声组(P<0.05)。高温组脑线粒体Ca~(2+)升高与Ca~(2+)-ATPase活性增加,胞浆Ca~(2+)减少为复合因素使脑细胞缺血缺氧,酸中毒,致使Ca~(2+)泵失活,线粒体储存Ca~(2+)用降低所致,进而造成胞浆Ca~(2+)超载。线粒体Ca~(2+)超载均可造成细胞中毒损伤,Mg~(2+)可减轻Ca~(2+)内流,复合组Mg~(2+)升高是否为机体的保护性反应有待研究。
In order to observe the effect of high temperature and tarsonic sound on the mitochondrial Ca2 + and Mg2 + in rats, the atomic absorption spectrophotometer was used to detect the Ca ~ (2 +), Mg ~ (2+) content was measured. The results showed that: (1) Ca ~ (2 +) in brain mitochondria increased significantly in high temperature group compared with control group, noise group and compound group (P <0.01); (2) (P <0.05). (3) Compared with the control group, there was no significant change in the Mg 2+ content of the mitochondria in the high temperature group, the noise group and the compound group (P <0.05) > 0.05). The Mg2 + concentration in the complex group was significantly higher than that in the noise group (P <0.05). In high temperature group, the increase of mitochondrial Ca2 +, the increase of Ca2 + - ATPase activity and the decrease of Ca2 + in the cytoplasm resulted in cerebral ischemia and hypoxia, acidosis and Ca ~ (2+) pump is inactivated, and the mitochondrial storage Ca2 + is decreased, leading to Ca2 + overload in the cytoplasm. Overloading of mitochondrial Ca ~ (2+) can cause cell poisoning, Mg ~ (2+) can reduce Ca ~ (2+) influx and Mg ~ (2+) increase in the complex is the protective response of the body. the study.