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目的探讨乐卡地平对早期动脉动脉粥样硬化(AS)及其脂质过氧化损伤的影响。方法将32只日本大耳白兔随机分为正常对照组、高脂组、乐卡地平低剂量组和高剂量组。测量血脂、血压、组织超氧化物岐化酶(SOD)和丙二醛(MDA),并进行组织形态学观察。结果与高脂组比较,乐卡地平高剂量组动脉内膜完整,增厚不明显,少数管腔见局限性隆起病灶,内膜下散在泡沫细胞。主动脉组织中 SOD 显著增高(P<0.05),MDA 明显降低(P<0.05)。结论高剂量乐卡地平具有抑制早期动脉粥样硬化的作用,可能与其清除自由基、抗脂质过氧化作用有关。
Objective To investigate the effect of lercanidipine on early arterial atherosclerosis (AS) and its lipid peroxidation injury. Methods Thirty-two Japanese white rabbits were randomly divided into normal control group, high fat group, low-dose lercanidipine group and high-dose group. Blood lipids, blood pressure, tissue superoxide dismutase (SOD) and malondialdehyde (MDA) were measured and histomorphology was observed. Results Compared with the high-fat group, the high-dose leca-aldine group had intact arterial intima without significant thickening. In a small number of lumens, the localized lesions were localized, and the intima scattered in foam cells. The aorta tissue SOD was significantly higher (P <0.05), MDA was significantly lower (P <0.05). Conclusion High-dose lercanidipine can inhibit the early atherosclerosis, which may be related to the elimination of free radicals and anti-lipid peroxidation.