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目的探讨影响夫精宫腔内人工授精(IUI)妊娠率的相关影响因素。方法选取该院生殖医学中心接受夫精IUI周期治疗的173对夫妇,对270个周期进行回顾性分析。总结不孕妇女的年龄、不孕年限、不孕类型、不同治疗方案、IUI周期数及处理后精子活动总数(PTMS)与妊娠率的关系。结果 173对不孕夫妇行270个周期宫腔内人工授精,临床妊娠58例,周期妊娠率为21.48%。女方年龄<35岁的IUI周期妊娠率明显高于≥35岁,差异有统计学意义(P<0.05)。不孕年限>3年的周期妊娠率明显低于≤3年的妇女,差异有统计学意义(P<0.05)。促排卵治疗比自然周期有更好的妊娠结局,差异有统计学意义(P<0.05)。继发性不孕与原发性不孕的周期妊娠率差异无统计学意义(P>0.05)。不同IUI周期数(1次、2次、≥3次)的妊娠率分别为15.6%、31.2%、35%,3组间差异有统计学意义(P<0.05)。处理后PTMS>10×106与≤10×106相比,妊娠率升高,但两者差异无统计学意义(P>0.05)。结论夫精IUI中,女方年龄、不孕年限、治疗方案、IUI周期数是影响IUI妊娠率的相关因素。
Objective To investigate the influencing factors of pregnancy rate of intrauterine insemination (IUI) in Fufang. Methods A total of 173 couples treated with IUI, a fertility medicine center, were retrospectively analyzed in 270 cycles. The relationship between infertile women’s age, infertility duration, types of infertility, different treatment regimens, number of IUI cycles and the total number of sperm motility after treatment (PTMS) and pregnancy rate were summarized. Results Of 173 infertile couples, 270 cycles of intrauterine insemination were performed, 58 were clinical pregnancies, and the cycle pregnancy rate was 21.48%. The IUI cycle pregnancy rate of women <35 years of age was significantly higher than that of ≥35 years of age, the difference was statistically significant (P <0.05). The pregnancy rates of cycles of infertility> 3 years were significantly lower than those of women ≤ 3 years (P <0.05). Ovulation treatment has better pregnancy outcomes than the natural cycle, the difference was statistically significant (P <0.05). There was no significant difference in the rate of pregnancy between secondary infertility and primary infertility (P> 0.05). The pregnancy rates of different IUI cycles (1, 2 and 3 times) were 15.6%, 31.2% and 35%, respectively. The differences among the 3 groups were statistically significant (P <0.05). After treatment PTMS> 10 × 106 and ≤ 10 × 106 compared to the pregnancy rate increased, but the difference between the two was not statistically significant (P> 0.05). Conclusions In the IUI, the age of female, the duration of infertility, the treatment regimen, the number of IUI cycles are the related factors that influence the pregnancy rate of IUI.