麻风杆菌接种先天性无胸腺小鼠发生的瘤型样损害

• 作 者: 王荷英
• 出 处: 国外医学参考资料.皮肤病学分册
• 发表日期: 1978年03期
• 关键词: 麻风杆菌 无胸腺 隔离间 死子 免疫缺陷 麻风菌 消耗性疾病 麻风菌素试验 病原体 麻风瘤

作者用具有免疫缺陷的先天性无胸腺小鼠(又称裸鼠)作麻风杆菌接种,期望产生病变并得到比正常小鼠更明显的麻风杆菌繁殖。先天无胸腺小鼠由于全身虚弱,大多数在生后2周内死亡,25周终于全部死亡,通常死子3～14周龄时。但若将其放在无菌或无特殊病原体的条件下饲养,能延长其寿命。因此,为了防止先天性无胸腺小鼠发生消耗性疾病及感染其他微生物,作者置小鼠于乙稀基塑料隔离间的无特殊病原体条件下饲养。本文介绍了

The authors used immunodeficient congenital athymic mice (also known as nude mice) for leprosy inoculation, expect to produce lesions and get more obvious than normal mice leprosy reproduction. Congenital athymic mice due to general weakness, most died within 2 weeks after birth, 25 weeks and finally all died, usually 3 to 14 weeks old when the dead. However, keeping them sterile or without special pathogens can prolong their lifespan. Therefore, in order to prevent congenital athymic mice wasting disease and infection of other microorganisms, the mice were housed in a vinyl-free plastic isolates without special pathogens feeding conditions. This article describes the