15例Down氏综合征患者姐妹染色单体互换(SCE)频率的研究

• 作 者: 赵蓥 张俊才 叶丽珍 罗会元 秦梅
• 机 构: 中国医学科学院基础医学研究所,中国医学科学院基础医学研究所,中国医学科学院基础医学研究所,中国医学科学院基础医学研究所,首都医院
• 出 处: 中国医学科学院学报
• 发表日期: 1982年05期
• 关键词: 染色单体互换 综合征 Down SCE 白血病 细胞动力学 致突变剂 检测环境 致畸 外周血培养

近年来,姐妹染色单体互换(简称SCE)频率的研究,在DNA损伤与修复、细胞动力学、检测环境中致畸致突变剂以及癌变机理等探讨中已广泛地得到应用。已有报道,白血病患者外周血淋巴细胞中SCE频率高于正常人。Down氏综合征者患易罹患白血病,癌变的危险性明显高于正常人,甚至高达10～20倍。为了研究Down氏综合征患者与正常人SCE频率可能存在的差异及与并发白血病之间可能存在的联系,我们检测15例Down氏综合征患者外周血淋

In recent years, the study on the frequency of sister chromatid exchange (SCE) has been widely used in the research of DNA damage and repair, cell kinetics, teratogenic and mutagenic agents in the detection of the environment and the mechanism of carcinogenesis. It has been reported that leukemia patients with peripheral blood lymphocyte SCE frequency higher than normal. Down’s syndrome is susceptible to suffering from leukemia, the risk of cancer was significantly higher than normal, or even up to 10 to 20 times. To investigate the possible differences in SCE frequency between Down’s syndrome and normal subjects and the possible association with concurrent leukemia, we examined 15 patients with Down’s syndrome