论文部分内容阅读
目的研究玻璃体腔中过氟丙烷气体对兔眼电生理和视网膜结构的影响。方法８只兔眼玻璃体内注入Ｃ３Ｆ８０．３ｍｌ，观察了术后ｄ３和ｄ７ＥＲＧ－ｂ波和视觉层诱发电位（ｖｉｓｕａｌｅｖｏｋｅｄｐｏｔｅｎｔｉａｌ，ＶＥＰ）的振幅以及视网膜结构的变化。结果在注气后ｄ３视网膜电流图（ｅｌｅｃｔｒｏｒｅｔｉｎｏｇｒａｍ，ＥＲＧ）－ｂ波明显降低（Ｐ＜０．０５），ｄ７恢复正常（Ｐ＞０．０５），ＶＥＰ振幅无明显变化（Ｐ＞０．０５），在ｄ４气体可达到最大膨胀体积，膨胀的气体形成一个占据８０％以上玻璃体腔的空腔，玻璃体被压缩成一薄层附于视网膜表面，２只眼晶体轻度混浊，视网膜无明显结构损害。结论玻璃体内注入Ｃ３Ｆ８可形成一个较大的空腔，为进行玻璃体内药物灌注和玻璃体大量积血等实验提供了良好的实验模型。
Objective To study the influence of perfluoropropane gas in the vitreous cavity on electrophysiological and retinal structures in the rabbit eye. Methods Eight rabbit eyes were intravitreally injected with C3F80.3ml. The amplitude of d3 and d7ERG-b wave and visual evoked potential (VEP) and the changes of retinal structure were observed. Results The level of ERG-b was significantly decreased (P <0.05) and d7 returned to normal (P> 0.05), while the amplitude of VEP did not change significantly after gas injection (P> 0.05) In d4, the gas reaches the maximum expansion volume. The expanded gas forms a cavity that occupies more than 80% of the vitreous cavity. The vitreous is compressed into a thin layer attached to the surface of the retina. The 2 eyes are slightly turbid and the retina has no obvious structural damage. Conclusion Intravitreal injection of C3F8 can form a large cavity, which provides a good experimental model for experiments such as intravitreal drug infusion and massive hemorrhage of vitreous body.