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目的:观察不同剂量的质子泵抑制剂在消化性溃疡出血病症治疗中的应用与效果。方法:采取数字随机法将我院收治的111例消化溃疡出血患者分成甲乙丙三组各37例,分别给予其40mg、80mg、120mg奥美拉唑应用,观察三组治疗效果。结果:乙组治疗总有效率为94.59%,同甲组的72.93%比较,差异显著(P<0.05),同丙组的97.30%比较,无显著差异(P>0.05);且三组不良反应发生率分别为0%、2.70%、5.41%,无比较差异(P>0.05)。结论:针对临床消化性溃疡出血患者,给予其中剂量质子泵抑制剂应用,效果显著,且安全性高,值得推广。
Objective: To observe the application of different doses of proton pump inhibitors in the treatment of peptic ulcer bleeding and its effects. Methods: A total of 111 patients with peptic ulcer hemorrhage treated in our hospital were divided into three groups according to random number method. 37 patients were treated with 40 mg, 80 mg and 120 mg omeprazole respectively. The therapeutic effect was observed in the three groups. Results: The total effective rate of group B was 94.59%, which was significantly higher than that of group A (72.93%) (P <0.05), but no significant difference compared with 97.30% of group C (P> 0.05) The incidence rates were 0%, 2.70% and 5.41%, respectively, with no significant difference (P> 0.05). Conclusion: For patients with peptic ulcer bleeding, the application of mid-dose proton pump inhibitor has significant effect and high safety, which deserves promotion.