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组胺已成为目前食物中毒,尤其是食用腐败金枪鱼引起的类似过敏反应的原因。此类食物中毒出现的症状与用组胺药相似。可是,值得注意的是人或各种实验动物口服纯组胺后,却缺乏毒性反应。有一种解释:可能组胺的毒性效力是由于腐败金枪鱼中存在有组胺代谢酶抑制物,使酶活性受抑制而发挥作用。目前已知肠内存在有两种主要的组胺代谢酶,即组胺-N-甲
Histamine has become the cause of the current food poisoning, especially the similar allergic reaction caused by the consumption of corpulent tuna. The symptoms of such food poisoning and histamine similar. However, it is noteworthy that human or various experimental animals oral pure histamine, but the lack of toxic reactions. There is an explanation: It is possible that the toxic effect of histamine is due to the presence of histamine metabolite inhibitors in corrupted tuna, which act to inhibit enzyme activity. It is currently known that there are two main histamine metabolizing enzymes in the intestine, histamine-N-methyl