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使内源性胰岛素增高或腹腔注射低于惊厥剂量的胰岛素(1.01U/kg)均可使大鼠脑中5-羟色胺(5-HT)与色氨酸浓度增高。含5-HT的脑神经元可能对睡眠的控制、温度调节、运动、食物消耗、痛觉和性活动起作用。实验用30只成年雄性大鼠分成3组,将不锈钢圆头螺旋电极钉入实验鼠颅骨,引导额-枕叶脑电图(EEG),腹腔内注射高剂量葡萄糖(2.5g/kg)和非-惊厥剂量胰岛素的合并给药,使大鼠睡眠—觉醒周期改变:在整个EEG连续记录8h中,第1～第5个小时,快速眼动(REM)睡眠时间明显减少,在第3、第4
Elevated concentrations of serotonin (5-HT) and tryptophan in the rat brain by increasing endogenous insulin or by intraperitoneal injection of insulin below the convulsant dose (1.01 U / kg). Brain neurons with 5-HT may play a role in sleep control, thermoregulation, exercise, food consumption, pain and sexual activity. Thirty male adult rats were randomly divided into three groups. The stainless steel round spiral electrodes were implanted into the skull of the experimental rats. The frontal-occipital lobe electroencephalography (EEG), intraperitoneal injection of high dose glucose (2.5g / kg) - Convulsive dose of insulin combined administration, the rat sleep-wake cycle changes: the entire EEG continuous recording 8h, 1 to 5 hours, REM sleep time significantly reduced in the 3rd, 4