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为研究单纯性近视与遗传的关系及它的遗传方式,用群体研究法调查了434个患者家系,包括1057个核心家系进行分析。分析结果表明:单纯近视存在着明显的遗传倾向。家系法分析,符合常染色体隐性遗传(AutosomalrecessiveinheritanceAR)方式。用Li-Mantel-Gart法计算出分离比0.2699,95%可信区间0.2899—0.2499,与AR理论值0.25接近,符合AR遗传方式。研究结果可为家族性单纯性近视的病因诊断和预防提供参考依据。
To study the relationship between simple myopia and heredity and its genetic pattern, 434 patient families, including 1057 nuclear families, were investigated using population studies. The results show that: simple myopia there is a clear genetic predisposition. Family law analysis, in line with autosomal recessive inheritance (Autosomal recessiveAR) way. The Li-Mantel-Gart method was used to calculate the separation ratio of 0.2699 and 95% confidence interval of 0.2899-0.2499, which was close to the theoretical value of AR of 0.25, which was in line with AR genetic mode. The results provide a reference for the diagnosis and prevention of familial simple myopia.