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目的:观察研究阿司匹林联合不同剂量丙种球蛋白治疗川崎病的临床效果。方法:选取2010年4月至2015年10月我院诊治的川崎病的患儿50例,随机分成对照组和观察组,每组25例;观察组患儿每天给予用量为2g/kg丙种球蛋白,治疗组患儿每天给予用量为400mg/kg丙种球蛋白,两组均联合阿司匹林进行治疗;对比分析两组患儿的治疗总有效率以及两组患儿在治疗前后C反应蛋白(CRP)、血小板(PLT)及血沉(ESR)的变化情况。结果:经过治疗后,观察组患儿的治疗有效率为96.00%,显著优于对照组的84.00%,比较差异值P<0.05,有统计学意义;观察组患儿治疗前后CRP、PLT、ESR的下降速度优于对照组,比较差异值P<0.05,有统计学意义。结论:大剂量丙种球蛋白联合阿司匹林治疗川崎病疗效显著,大大缩短患儿的退热时间,明显降低患儿CRP、PLT、ESR水平,能使患儿早日康复出院,值得推广。
Objective: To observe the clinical effect of aspirin combined with different doses of gamma globulin in the treatment of Kawasaki disease. Methods: Fifty children with Kawasaki disease diagnosed and treated in our hospital from April 2010 to October 2015 were randomly divided into control group and observation group, with 25 cases in each group. The children in observation group were administered with 2g / kg gamma bulb The patients in the treatment group were treated with 400 mg / kg gamma globulin daily, and both groups were treated with aspirin. The total effective rate of the two groups was compared with that of the two groups before and after treatment. C-reactive protein (CRP) , Platelet (PLT) and erythrocyte sedimentation rate (ESR) changes. Results: After treatment, the effective rate of treatment group was 96.00%, which was significantly better than that of control group (84.00%), the difference was significant (P <0.05), the difference was statistically significant. The CRP, PLT, ESR The rate of decline is better than the control group, the difference was P <0.05, with statistical significance. Conclusion: High dose gammaglobulin combined with aspirin has a significant therapeutic effect on Kawasaki disease, which can greatly shorten the antipyretic time of children and significantly reduce the levels of CRP, PLT and ESR in children and make it possible for children to be discharged and rehabilitated as soon as possible.