Computer Simulation of Gd(III) Speciation in Human Interstitial Fluid

• 出 处: Chinese Chemical Letters
• 发表日期: 2003年02期
• 关键词: constants contained insoluble interstitial inorganic hydroxyl precipitate contin

The speciation and distribution of Gd(III) in human interstitial fluid was studied by computer simulation. Meantime artificial neural network was applied to the estimation of log ?values of complexes. The results show that the precipitate species, GdPO4 and Gd2(CO3)3, are the predominant species. Among soluble species, the free Gd(III), [Gd(HSA)] , [Gd(Ox)] and then the ternary complexes of Gd(III) with citrate are main species and [Gd3(OH)4] becomes the predominant species at the Gd(III) total concentration of 2.2?0-2mol/L.

The findings and that of Gd (III) in human interstitial fluid was studied by computer simulation. Meantime artificial neural network was applied to the estimation of log? Values ​​of complexes. The results show that the precipitate species, GdPO4 and Gd2 (CO3) 3 Among the predominant species. Among soluble species, the free Gd (III), [Gd (HSA)], [Gd (Ox)] and then the ternary complexes of Gd (III) with citrate are main species and [Gd3 ) 4] becomes the predominant species at the Gd (III) total concentration of 2.2? 0-2 mol / L.