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急性实验中，间隔５ｍｉｎ反复ｉｐＮ受体激动剂烟碱０．５，１．０，１．０，２．０，２．０ｍｇ·ｋｇ－１可显著提高大鼠颌下腺中肌醇含量，并为Ｎ受体拮抗剂美加明１．０ｍｇ·ｋｇ－１对抗，为肌醇磷酸酶抑制剂氯化锂６９．４ｍｇ·ｋｇ－１ｉｐ翻转；一次性ｉｐＭ受体激动剂槟榔碱２００ｍｇ·ｋｇ－１也可显著提高颌下腺肌醇含量，并为Ｍ受体拮抗剂阿托品２．０ｍｇ·ｋｇ－１对抗；反复注射烟碱后，再ｉｐ不影响肌醇含量的槟榔碱５０ｍｇ·ｋｇ－１，两者产生协同效应，进一步提高肌醇含量．慢性实验中，每日２次ｓｃ烟碱２．０－５．０ｍｇ·ｋｇ－１或槟榔碱２．０－１０．０ｍｇ·ｋｇ－１１４ｄ后，均可使大鼠颌下腺中肌醇含量显著降低．
In acute experiment, 0.5, 1.0, 1.0, 2.0 and 2.0 mg · kg-1 of ipN agonist nicotine at 5 minute intervals significantly increased inositol content in rat submaxillary gland N receptor antagonist methicillin 1.0mg · kg-1 confrontation, for the inositol phosphatase inhibitor lithium lithium 69.4mg · kg-1ip reversal; one-time ipM receptor agonist arecoline 200mg · kg-1 also Can significantly improve the submandibular inositol content, and M receptor antagonist atropine 2.0mg · kg-1 confrontation; after repeated injection of nicotine, then ip does not affect the inositol content arecoline 50mg · kg-1, both produced Synergistic effect, to further improve inositol content. In the chronic experiment, inosine content in rat submandibular gland was significantly reduced after twice daily sc Nicotine 2.0-5.0 mg · kg-1 or arecoline 2.0-10.0 mg · kg-114 d .