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1957年 Creech 首次用细胞抑制剂行隔离的肢体灌注治疗有肢体范围内转移的恶性黑色素瘤病人,Cavaliere 则证明同时加温能提高细胞抑制剂的疗效。Lejeune 首次在恶性黑色素瘤病人联合用重组人体肿瘤坏死因子(rhTNF-α)和米尔法兰行隔离的肢体灌注,提高了有肢体内转移或卫星结节病人
In 1957, Creech was the first to use isolated limb perfusion with cytostatics to treat patients with metastatic melanoma in the limb and Cavaliere demonstrated that simultaneous warming can improve the efficacy of cytostatics. Lejeune for the first time in patients with malignant melanoma combined with recombinant human tumor necrosis factor (rhTNF-α) and miRNA flange in isolated limbs to enhance patients with metastases or satellite nodules in limbs