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抗高血压疗法虽已成功地预防了高血压的多种并发症,但对动脉粥样硬化和冠心病并发症无明显影响。可能因为,动脉粥样硬化始于生命早期,但抗高血压疗法多数施于那些已有冠脉疾病的中、老年人,治疗仅持续数年;有些抗高血压药(尤其是噻嗪类、β阻滞剂)的代谢不良影响,可能促发冠脉疾病。左室肥大(LVH)是心血管病的主要危险因素之一:高血压伴LVH患者中,心肌梗塞、需要冠脉旁路移植术的心绞痛、卒中、心脏猝死、充血性心力衰竭等危险增加5倍。LVH危险随着年龄增长和肥胖而递增。
Although antihypertensive therapy has successfully prevented a variety of complications of hypertension, but no significant effect on atherosclerosis and coronary heart disease complications. Probably because atherosclerosis starts early in life, antihypertensives are mostly applied to those who have had coronary artery disease and the treatment lasts only for years; some antihypertensives, especially thiazides, β blockers) of the metabolic adverse effects, may trigger coronary disease. Left ventricular hypertrophy (LVH) is one of the major risk factors for cardiovascular disease: increased risk of myocardial infarction, angina pectoris requiring coronary artery bypass grafting, stroke, sudden cardiac death, and congestive heart failure in hypertensive patients with LVH 5 Times The risk of LVH increases with age and obesity.