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目的探讨P-选择素在不稳定性心绞痛(UA)发生、发展中的作用,以及与脂质代谢、氧化应激的相关性。方法选择病例组冠心病(CHD)患者68例,包括稳定性心绞痛(SA)患者20例,UA患者48例,对照组正常人20例,分别测定血浆和血小板内P-选择素含量以及血脂(血清TC、TG、LDL-C、HDL-C)、超氧化物歧化酶(SOD)、丙二醛(MDA)含量,同时分析P-选择素与血脂、脂质过氧化物的相关性。结果UA患者血浆及血小板内P-选择素含量均显著高于SA患者和正常对照者(均P<0·01),而SA患者血浆及血小板内P-选择素含量与正常对照组相比差异无统计学意义(P>0·05)。血浆P-选择素与血小板P-选择素、TG、LDL-C、MDA水平成明显正相关(均P<0·01),而与SOD水平成明显负相关(P<0·01)。结论UA患者体内P-选择素含量明显升高,提示血小板活性增强,其原理可能与脂质代谢紊乱以及氧化应激增强有关。
Objective To investigate the role of P-selectin in the occurrence and development of unstable angina pectoris (UA), and its relationship with lipid metabolism and oxidative stress. Methods Sixty-eight patients with coronary heart disease (CHD) were selected and included 20 patients with stable angina pectoris (SA), 48 patients with UA, and 20 normal subjects. The levels of plasma P-selectin and blood platelet Serum TC, TG, LDL-C, HDL-C), superoxide dismutase (SOD) and malondialdehyde (MDA) were measured. The correlation between P-selectin and blood lipids and lipid peroxides was also analyzed. Results The levels of plasma and platelet P-selectin in UA patients were significantly higher than those in SA patients and normal controls (all P <0.01), while the levels of P-selectin in plasma and platelets in patients with UA were significantly lower than those in normal controls No statistical significance (P> 0.05). There was a significant positive correlation between plasma P-selectin and P-selectin, TG, LDL-C and MDA (all P <0.01), but negatively correlated with SOD (P <0.01). Conclusions The content of P-selectin in patients with UA is significantly increased, suggesting that the activity of platelets is enhanced. The principle may be related to disorders of lipid metabolism and the increase of oxidative stress.