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目的对儿童急性淋巴细胞白血病(ALL)中的染色体核型及融合基因进行分析。方法应用骨髓染色体标本及FISH方法对38例儿童ALL患者做染色体核型分析及融合基因检测。结果 38例检测患儿中发现染色体异常核型7例;融合基因检测阳性者12例,其中7例是TEL/AML1阳性。结论细胞遗传学联合融合基因检测有助于儿童ALL的诊断及预后判断分析。
Objective To analyze the chromosomal karyotypes and fusion genes in childhood acute lymphoblastic leukemia (ALL). Methods Chromosome karyotype analysis and fusion gene detection were performed in 38 pediatric ALL patients using bone marrow chromosome and FISH. Results Seven cases of chromosomal abnormalities were detected in 38 cases. Twelve cases were positive in fusion gene test, of which 7 cases were TEL / AML1 positive. Conclusion The combination of cytogenetics and fusion gene is helpful for the diagnosis and prognosis analysis of childhood ALL.