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目的对白细胞分离术联合化疗治疗高白细胞急性白血病(hyperleucocytic acute leukemiasHLAL)进行疗效观察。方法对20例HLAL患者采用白细胞分离术1～3次后,立即诱导缓解化疗,同时选择15例HLAL患者单纯化疗作为对照,比较两者疗效。结果采用白细胞分离术,20例患者完全缓解率(CR)率达55%,明显高于单纯化疗组(33%),早期病死率为15%,明显低于对照组(36%)。结论白细胞分离术结合化疗,能提高CR率,减少单纯化疗引起的不良后果。白细胞分离术联合化疗治疗高白细胞急性白血病疗效显。
Objective To observe the effect of leukocyte isolation combined with chemotherapy on hyperleucocytic acute leukemia (HLL). Methods Twenty patients with HLAL were treated with leukapheresis one to three times immediately after induction of chemotherapy. Meanwhile, 15 patients with HLAL were selected as the control, and the curative effect was compared. Results The complete remission (CR) rate was 55% in 20 patients, which was significantly higher than that in the chemotherapy alone group (33%). The early mortality was 15%, which was significantly lower than that in the control group (36%). Conclusion Leukocyte isolation combined with chemotherapy can improve the CR rate and reduce the adverse consequences of chemotherapy alone. Leukocyte isolation combined with chemotherapy for treatment of high white blood cell acute leukemia.