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[目的]测定急性冠脉综合征(ACS)患者血清同型半胱氨酸(Hcy)水平,探讨血清Hcy水平与ACS严重程度的关系。[方法]将108例ACS患者分为不稳定性心绞痛(UA)组51例和急性心肌梗塞(AMI)组57例,其中75例根据冠状动脉造影结果又分为冠脉病变一支、二支、三支及以上组。以50例健康体检者作为对照组。测定各组血清Hcy水平,并进行统计学分析。[结果]血清Hcy水平UA组(15.40±5.51)μmol/L、AMI组(20.39±6.43)μmol/L,与对照组(10.21±3.61)μmol/L比较差异有显著性意义(P<0.01),UA组与AMI组比较,差异有显著性意义(P<0.01)。通过单因素方差分析,冠脉病变一支组(12.63±5.20)μmol/L、二支组(15.40±2.11)μmol/L和三支及以上组(21.56±5.89)μmol/L之间血清Hcy水平比较差异有显著性意义(F=23.803,P<0.01),且随病变支数增加,血清Hcy水平逐渐升高,提示患者血清Hcy水平与冠状动脉受累支数具有正相关性。对照组和一支组(P<0.05)、一支组和二支组(P<0.05)、二支组和三支及以上冠脉病变组(P<0.01)之间Hcy水平比较差异均有显著性意义。[结论]ACS患者血清Hcy水平显著高于正常人群,并与冠状动脉受累支数及疾病严重程度有正相关性。测定血清Hcy水平可能对ACS的预防和治疗监测具有重要临床意义。
[Objective] To determine the serum homocysteine (Hcy) level in patients with acute coronary syndrome (ACS) and to explore the relationship between the serum Hcy level and the severity of ACS. [Methods] 108 patients with ACS were divided into unstable angina (UA) group 51 and acute myocardial infarction (AMI) group 57 cases, of which 75 cases were divided according to coronary angiography coronary artery lesions, two , Three or more groups. Fifty healthy subjects were taken as the control group. Serum Hcy levels were measured and statistically analyzed. [Results] Serum Hcy levels in the UA group (15.40 ± 5.51) μmol / L and AMI group (20.39 ± 6.43) μmol / L were significantly different from those in the control group (10.21 ± 3.61) μmol / L (P <0.01) There was significant difference between UA group and AMI group (P <0.01). One-way analysis of variance (ANOVA) showed that the serum levels of Hcy in one group (12.63 ± 5.20) μmol / L, 15.40 ± 2.11 μmol / L in the second group and 21.56 ± 5.89 μmol / L in the three groups (F = 23.803, P <0.01). With the increase of lesion count, the level of serum Hcy gradually increased, which indicated that there was a positive correlation between serum Hcy level and coronary artery involvement count. (P <0.05). There was significant difference in Hcy between the two groups and the three branches or more of coronary artery disease group (P <0.01) Significant significance. [Conclusion] The serum Hcy level in patients with ACS is significantly higher than that in normal people, and has a positive correlation with the number of coronary artery involvement and the severity of the disease. Measurement of serum Hcy levels may have important clinical implications for the prevention and treatment of ACS.