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目的:观察艾迪注射液对直肠癌术后患者生存质量的影响。方法:将70例直肠癌根治术后进行XELOX方案化疗的患者随机分为对照组和艾迪组各35例,2组均予化疗方案治疗,艾迪组在化疗基础上加用艾迪注射液治疗,疗程均为3个化疗周期。化疗过程中记录患者的不良反应发生情况,监测患者血常规及肝肾功能,化疗前及疗程结束后均对患者进行中医生存质量量表(QLQ-CMPPCC)及Karnofsky(KPS)评分。结果:艾迪组KPS提高率为62.86%,优于对照组的34.29%,2组相比,差异有统计学意义(P<0.01)。化疗前,2组QLQ-CMPPCC评分及KPS评分比较,差异均无统计学意义(P>0.05)。疗程结束后,2组QLQ-CMPPCC评分、KPS评分均较治疗前上升(P<0.01,P<0.05),艾迪组QLQ-CMPPCC评分、KPS评分均高于对照组(P<0.01,P<0.05)。艾迪组患者胃肠道不适、白细胞减少、贫血及肝功能异常的发生例数均少于对照组,差异均有统计学意义(P<0.05,P<0.01),血小板减少、周围神经炎的发生情况2组相当(P>0.05)。结论:直肠癌术后辅助化疗患者使用艾迪注射液可增强免疫力,减轻化疗药物的不良反应,提高生活质量,临床效果明显。
Objective: To observe the effect of Aidi Injection on the quality of life of postoperative patients with rectal cancer. Methods: Seventy patients with XELOX regimen after radical resection of rectal cancer were randomly divided into control group and Aidi group (35 cases each). The two groups were given chemotherapy regimen. In the Aidi group, Treatment, treatment are three cycles of chemotherapy. Recorded during chemotherapy in patients with adverse events, patient monitoring blood and liver and kidney function, all of the patients chemotherapy before and after treatment of TCM Quality of Life Scale (QLQ-CMPPCC) and Karnofsky (KPS) score. Results: The improvement rate of KPS in Aidi group was 62.86%, which was better than 34.29% in control group. There was significant difference between two groups (P <0.01). Before chemotherapy, the QLQ-CMPPCC scores and KPS scores in the two groups showed no significant difference (P> 0.05). After treatment, QLQ-CMPPCC score and KPS score in two groups were significantly higher than those before treatment (P <0.01, P <0.05). QLQ-CMPPCC and KPS in Aidi group were higher than those in control group (P <0.01, 0.05). The number of cases of gastrointestinal discomfort, leukopenia, anemia and liver dysfunction in the Aidi group were less than those in the control group, with significant differences (P <0.05, P <0.01), thrombocytopenia, peripheral neuritis The occurrence of the situation in the two groups (P> 0.05). Conclusion: Adjuvant chemotherapy in patients with rectal cancer using Aidi injection can enhance immunity, reduce the adverse reactions of chemotherapy drugs, improve quality of life, the clinical effect is obvious.