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目的探讨不同呼气末气道正压(PEEP)水平对急性肺损伤(ALI)/急性呼吸窘迫综合征(ARDS)患者的氧合指数(OI)及诊断的影响。方法观察满足ALI/ARDS诊断的9例患者在不同PEEP水平(PEEP=0、5、10、15cmH2O)时OI的变化。结果 PEEP对ALI/ARDSI患者OI有明显影响(P<0.05)。与0cmH2OPEEP相比,PEEP为5cmH2O时,OI的升高无明显影响(P>0.05);而PEEP为10、15cmH2O,OI有明显的升高(P<0.05);PEEP为5、10、15cmH2O时,组间OI比较差异有统计学意义(P<0.05)。同时,随着PEEP增加,满足ALI/ARDS诊断标准的例数逐渐减少。结论 PEEP对OI有明显影响,从而直接影响ALI/ARDS的诊断结果。
Objective To investigate the effects of different levels of end-expiratory pressure (PEEP) on oxygenation index (OI) and diagnosis of patients with acute lung injury (ALI) / acute respiratory distress syndrome (ARDS). Methods The changes of OI in 9 patients with ALI / ARDS diagnosed at different PEEP levels (PEEP = 0, 5, 10, 15cmH2O) were observed. Results PEEP had significant effect on OI of patients with ALI / ARDSI (P <0.05). Compared with 0cmH2OPEEP, PEI of 5cmH2O had no significant effect on the increase of OI (P> 0.05), while PEEP of 10,15cmH2O and OI increased obviously (P <0.05). When PEEP was 5,10,15cmH2O , There was significant difference in OI between groups (P <0.05). At the same time, as PEEP increases, the number of patients meeting the criteria for ALI / ARDS declines. Conclusion PEEP has a significant effect on OI, which directly affects the diagnosis of ALI / ARDS.