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应用药物减少摄食是医治肥胖症的一种重要方法。目前多数食欲抑制药不是在化学上同苯丙胺有关,就是在作用方式上与之相似,应用时存在一些问题。因此,作用机制不同的新型食欲抑制药可能在治疗中发挥重要作用。研究控制食欲的神经化学系统时发现,纳洛酮及其他阿片拮抗剂减少实验动物的摄食,说明内源性阿片样物质在控制摄食中具有某种功能。本文报道,6种阿片拮抗剂对大鼠摄食的影响,并与两种临床应用的食欲抑制药芬氟应明(Fenfluamine)和乙胺苯丙酮(Di-ethylpropion)作比较。
Using drugs to reduce food intake is an important way to treat obesity. At present, most of the appetite suppressants are not chemically related to amphetamines, that is, their mode of action is similar, and there are some problems in application. Therefore, new appetite suppressants with different mechanisms of action may play an important role in the treatment. Research on appetite-controlling neurochemicals found that naloxone and other opioid antagonists reduced the intake of laboratory animals, suggesting that endogenous opioids have some function in controlling feeding. This article reports the effects of six opioid antagonists on ingestion in rats and compares them with two clinically used appetite suppressants Fenfluamine and Di-ethylpropion.