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随着医药科学的发展,临床合并用药日益增多,出现了极其复杂的相互作用:或使作用增强、延效,或减弱、拮抗,或增大毒性。据统计同用1～5种药物的病人,药物反应率为18.6％,6种以上可上升到81.4％。且有引起死亡的危险。因此,合理用药,提高疗效,确保安全,就成为临床药学和临床治疗学上的日益突出的问题!现据国内外资料综述如下: 一、药物相互作用影响吸收
With the development of medical science, the clinical combination of medication is increasing, there has been an extremely complex interaction: or to enhance the role, delay, or weakened, antagonistic, or increase toxicity. According to the statistics, 1 to 5 kinds of drugs are used in patients with drug reaction rate of 18.6%, 6 or more can rise to 81.4%. And there is the danger of causing death. Therefore, the rational use of drugs to improve efficacy and ensure safety has become an increasingly prominent issue in clinical pharmacy and clinical therapeutics! According to domestic and foreign materials are summarized as follows: First, the drug interactions affect the absorption