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本文综述1980年日本国内发表的抗生素论文(128篇)及专利(71份),不包括抗生素的纯化学和与微生物、酶反应无关的研究。β-内酰胺类抗生素自硫霉素(Thienamycins)发现以来,碳青霉烯(Carbapenem)骨架和抑制β-内酰胺酶活性的第三代抗生素最为引人注目。从产生PS-5的乳脂色链霉菌A271和暗黄绿链霉菌A933的培养液中分离到PS-6和PS-7,而且产生表硫霉素(Epithienamycin)的黄灰链霉菌NRRL8139和产生橄榄酸的橄榄色链霉菌ATCC3126也能少量产生这两物质。所以,PS-6和PS-7的产生不是菌株特异的,
This article reviews the 80 antibiotic articles published in Japan in 1980 and 71 patents, excluding pure antibiotics and studies unrelated to microorganisms and enzyme reactions. β-Lactam antibiotics The third generation of antibiotics, the carbapenem backbone and the β-lactamase-inhibiting third-generation antibiotic, is the most notable since the discovery of Thienamycins. PS-6 and PS-7 were isolated from a culture broth of PS-5-producing Streptomyces coelicolor A271 and Streptomyces aureus, and Streptomyces yellow-greenery NRRL8139 producing Epithienamycin Olive Streptomyces ATCC3126 also produce these two substances in small quantities. Therefore, the production of PS-6 and PS-7 is not strain-specific,