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已知手术损伤机体免疫反应,虽然损伤机理尚不明了,但最终的影响是增加了术后脓毒症发生的风险。为阐明术后免疫抑制的可能机理,作者研究了细胞素和谷酰胺代谢之间的关系。在腹股沟疝修补术(小手术组)或选择性腹主动脉瘤手术(大手术组)前、中、后测定谷酰胺、谷氨酸盐、丙氨酸、支链氨基酸、IL-1、IL-6、TNF和IFN-γ的血浆值。大手术组病人9例,7例男性,2例女性,年龄59～83岁,均作腹主动脉瘤修补术,在麻醉诱导后取术前血样,作切口后0.5、1、1.5、2、2.5、3、3.5、4、6、8、12、24、48、72、96、120和168小时分别取血样。小手术组病人5例,4例男性,1例女性,年龄在
Known surgery damage the body’s immune response, although the mechanism of injury is not yet understood, but the final effect is to increase the risk of postoperative sepsis. To elucidate the possible mechanism of postoperative immunosuppression, the authors studied the relationship between cytokine and glutamine metabolism. Glutamate, glutamate, alanine, branched-chain amino acids, IL-1, IL were measured before, during, and after inguinal hernia repair (small surgery group) or selective abdominal aortic aneurysm surgery -6, plasma levels of TNF and IFN-γ. The patients in the major surgery group included 9 patients, 7 males and 2 females, aged 59-83 years. All patients underwent abdominal aortic aneurysm repair. Blood samples were taken before anesthesia induction for 0.5, 1, 1.5, 2.5, 3, 3.5, 4, 6, 8, 12, 24, 48, 72, 96, 120 and 168 hours respectively. Small surgery group of 5 patients, 4 males and 1 female, age at