帕金森病患者交感神经系统病理与~(123)I-间碘苄胍(MIBG)闪烁扫描中的心肌摄取率降低相对应

• 作 者: Mitsui J. Saito Y. Momose T. S. Murayama 张玉春
• 机 构: Department of Neuropathology Tokyo Metropolitan Institute of Gerontology 35- 2 Sakaecho Itabashi- k
• 出 处: 世界核心医学期刊文摘(神经病学分册)
• 发表日期: 2006年08期
• 关键词: 帕金森病 MIBG 闪烁扫描 摄取率 交感神经系统 脊髓中间外侧柱 交感神经节 心交感神经 形态学基础 神经病理学

Decreased cardiac uptake in 123I- metaiodobenzylguanidine (MIBG) scintigraphy has been adopted as one of the most reliable diagnostic tests for Parkinson disease (PD) in Japan. To investigate the morphological basis for this finding, we performed a detailed neuropathological study of the cardiac sympathetic nervous system of a 71- year- old autopsy- proven PD patient, who presented with a marked decrease in cardiac uptake of MIBG, just 1 year prior to death. We carefully examined the intermediolateral column at several levels of the thoracic spinal cord, the sympathetic trunk and ganglia, and the nerve plexus of the anterior wall of the left ventricle and compared the findings with those of five age- matched controls. We found that the cardiac plexus was more heavily involved than the sympathetic ganglia in this patient with PD. Our study may provide further evidence that the markedly decreased cardiac uptake of MIBG observed in PD cases represents preferential involvement of the cardiac sympathetic nerve plexus in this disorder.

Decreased cardiac uptake in 123I-metaiodobenzylguanidine (MIBG) scintigraphy has been adopted as one of the most reliable diagnostic tests for Parkinson disease (PD) in Japan. To investigate the morphological basis for this finding, we performed a detailed neuropathological study of the cardiac sympathetic nervous system of a 71- year-old autopsy- proven PD patient, who presented with a marked decrease in cardiac uptake of MIBG, just 1 year prior to death. We carefully examined the intermediolateral column at several levels of the thoracic spinal cord, the sympathetic trunk and ganglia, and the nerve plexus of the anterior wall of the left ventricle and compared the findings with those of five of age-matched controls. We found that the cardiac plexus was more heavily involved than the sympathetic ganglia in this patient with PD. Our study may provide further evidence that the markedly decreased cardiac uptake of MIBG observed in PD cases represents preferential involvement of the cardi ac sympathetic nerve plexus in this disorder.