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消化性溃疡为常见和重要的消化系疾病。溃疡的发生,主要由于胃酸和胃蛋白酶对胃肠道粘膜自身的消化和侵蚀。临床实践表明:胃酸缺乏者不发生胃溃疡(GU),十二指肠溃疡(DU)病人的基础胃酸排出量(BAO)比正常人高一倍多。因此,消化性溃疡的外科治疗原则均不外乎减少胃酸分泌和免遭胃酸侵蚀。兹就胃酸分泌的控制,胃粘膜屏障及消化性溃疡的发病机制等与外科治疗有关的生理学基础理论.简要介绍于后。
Peptic ulcer is a common and important digestive disease. The occurrence of ulcers is mainly due to gastric acid and pepsin digestion and erosion of the gastrointestinal mucosa itself. Clinical practice shows that gastric ulcers do not cause gastric ulcers (GU), and patients with duodenal ulcers (DU) have more than double the basal gastric acid output (BAO) than normal people. Therefore, the principles of surgical treatment of peptic ulcers are nothing more than reducing gastric acid secretion and protecting from acid attack. The physiology basic theories related to surgical treatment, such as the control of gastric acid secretion, the pathogenesis of gastric mucosal barrier and peptic ulcer, etc., are briefly introduced later.